Do you do a lot of work with files and folders? If so, you can halve the amount of mouse clicking you have to do by using single-clicks instead of double-clicks to open files and folders. See below for instructions on changing the Windows settings to achieve this.
You can no longer select an item by clicking on it, as a click will actually open the item. To just select an item, simply hover the mouse pointer over it. To select a list of items, hover your mouse over the first one, then hold down Shift and hover your mouse over the last item. This feature reduces your mouse clicking even further.